Pathophysiology Obesity is caused by an imbalance between energy and caloric intake. This disparity is believed to be under the control of genes and the environment. The discovery of immunological anomalies in obesity linked to the leptin-proopiomelanocortin system and the alpha (TNF-α) elevated tumor necrosis factor brought a new insight to obesity awareness.
• Genetic basis
• Environmental and behavioral origins
• Type 2 diabetes
• Insulin resistance
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